Vials

MOTS-c 40mg

Name: MOTS-c 40mg
Brand: Quanta Pharmaceuticals

A mitochondrial-derived peptide studied as an exercise mimetic via AMPK activation and metabolic regulation.

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP), encoded within the 12S rRNA region of the mitochondrial genome rather than nuclear DNA. It was first identified in a landmark 2015 Cell Metabolism paper (Lee et al.) as the first mitochondrial-encoded signal peptide shown to translocate to the cell nucleus and directly regulate nuclear gene expression — establishing an entirely new class of metabolic signalling molecule. In that and follow-up research, MOTS-c treatment prevented diet-induced obesity and reversed age-related muscle insulin resistance in mouse models. This 40mg lyophilised vial suits extended research protocols. Independent lab testing confirmed this batch at 99% purity with an actual content of 39.80mg, closely matching the 40mg label claim.

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Specifications

Peptide

MOTS-c

Sequence

16 Amino Acids

Dosage

40mg/vial

Purity

99%

Verified Content

39.80mg

Form

Lyophilised

Administration

Subcutaneous

Research Benefits

Exercise-mimetic activity — The founding 2015 study showed MOTS-c prevented diet-induced obesity and reversed age-related muscle insulin resistance in mouse models.
Insulin sensitivity — Studies demonstrate improved glucose uptake and metabolic regulation via AMPK activation.
Fat metabolism — Investigated for promoting fatty acid oxidation and reducing fat accumulation.
Mitochondrial function — Supports cellular energy production and mitochondrial biogenesis.
Novel signalling mechanism — The first mitochondrial-encoded peptide shown to translocate to the nucleus and directly regulate gene expression.

How It Works

MOTS-c is encoded within the 12S rRNA region of the mitochondrial genome rather than nuclear DNA, placing it in a unique class of signalling molecules known as mitochondrial-derived peptides. Its studied mechanism involves inhibiting the folate cycle and its associated purine biosynthesis pathway, which in turn activates AMPK (AMP-activated protein kinase) — the cell's central energy-sensing pathway. This triggers enhanced glucose uptake via GLUT4 upregulation in skeletal muscle, improved insulin sensitivity, and increased fatty acid oxidation, effects that mirror many metabolic adaptations seen with exercise.

The 2015 discovery paper additionally showed MOTS-c can translocate to the cell nucleus under metabolic stress, where it directly regulates nuclear gene expression — the first mitochondrial-encoded peptide shown to do so, adding a second, still-being-characterised layer to its studied activity.

⚠ For Research Use Only

This product is supplied strictly for in-vitro laboratory and preclinical research use. It is not a drug, food, dietary supplement, or cosmetic, and is not intended for human or animal consumption, diagnosis, treatment, or prevention of any disease. MOTS-c 40mg must be handled only by qualified individuals trained in proper laboratory safety procedures.

By purchasing, the buyer confirms this product is being acquired for legitimate research purposes and assumes full responsibility for its handling, storage, and use in compliance with all applicable local, national, and international laws.