Vials

5-Amino-1MQ 50mg

Name: 5-Amino-1MQ 50mg
Brand: Quanta Pharmaceuticals

A selective NNMT inhibitor studied for reducing fat-cell formation and preserving cellular NAD+ levels.

5-Amino-1MQ is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed at high levels in adipose tissue and liver that depletes the cell's nicotinamide and methyl-donor reserves — both needed for NAD+ synthesis. As a small molecule rather than a peptide, it is studied via oral administration. The foundational study (Neelakantan et al., Biochemical Pharmacology, 2018) dosed diet-induced obese mice with 5-Amino-1MQ at 20mg/kg, three times daily subcutaneously, for 11 days, and reported reduced body weight and white adipose mass, smaller adipocytes, and lower plasma cholesterol — notably, without any change in food intake, distinguishing its mechanism from appetite-suppressant compounds. A 2021 follow-up in Scientific Reports found that pairing an NNMT inhibitor with dietary changes reduced liver fat and hepatic steatosis beyond either intervention alone. All published evidence to date is from rodent models; human trial data has not yet been published. Independent lab testing confirmed the finished vial at 99% purity with an actual content of 52.53mg against the 50mg label claim.

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Specifications

Peptide

5-Amino-1MQ

Also Known As

5-Amino-1-methylquinolinium

Class

NNMT Inhibitor

Dosage

50mg/vial

Purity

99%

Verified Content

52.53mg

Form

Orange Powder

Administration

Oral

Storage

2-8°C, Dry

Research Benefits

NNMT inhibition — Selectively blocks the enzyme responsible for degrading NAD+ precursors and methyl donors.
Reduced adipogenesis — The foundational 2018 mouse study reported reduced body weight, smaller adipocytes, and lower plasma cholesterol.
Appetite-independent mechanism — Fat-mass reduction occurred without any change in food intake, distinguishing it from appetite-suppressant compounds.
Liver fat research — A 2021 follow-up study found reduced hepatic steatosis when paired with dietary changes.
Orally bioavailable — Maintains activity via oral administration, avoiding the need for injection.

How It Works

NNMT is an enzyme expressed at particularly high levels in adipose tissue and the liver, where it transfers a methyl group from SAM (S-adenosylmethionine) onto nicotinamide — a reaction that depletes both the cell's methyl-donor pool and its reserve of nicotinamide, the direct precursor to NAD+. By selectively inhibiting NNMT, 5-Amino-1MQ preserves both of these metabolic substrates.

Research in diet-induced obesity models has shown that NNMT inhibition reduces fat mass and improves cholesterol markers without suppressing appetite or caloric intake, working by preventing the metabolic drain NNMT otherwise imposes on adipose tissue. Its role in NAD+ preservation has also drawn separate interest in longevity research, given NAD+'s importance to sirtuin activity and mitochondrial biogenesis — though it's worth noting all of this evidence to date comes from rodent studies, with human trials yet to be published.

⚠ For Research Use Only

This product is supplied strictly for in-vitro laboratory and preclinical research use. It is not a drug, food, dietary supplement, or cosmetic, and is not intended for human or animal consumption, diagnosis, treatment, or prevention of any disease. 5-Amino-1MQ 50mg must be handled only by qualified individuals trained in proper laboratory safety procedures.

By purchasing, the buyer confirms this product is being acquired for legitimate research purposes and assumes full responsibility for its handling, storage, and use in compliance with all applicable local, national, and international laws.