Orals

Yohimbine

Name: Yohimbine
Brand: Quanta Pharmaceuticals

An alpha-2 adrenergic antagonist studied as a stimulant-based fat-loss and energy aid, particularly for stubborn fat.

Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree, studied extensively as an alpha-2 adrenergic receptor antagonist with applications in fat-loss and energy research. This formulation supplies 100 tablets of 10mg per tub. Chemically classified as C21H26N2O3, Yohimbine works by blocking alpha-2 adrenergic receptors, which are densely concentrated in stubborn fat deposits and normally inhibit lipolysis. Research has focused on its ability to override this inhibitory signal, thereby promoting fat mobilisation in areas that are typically resistant to other fat-loss approaches. Pharmacokinetic studies place yohimbine's own elimination half-life at under an hour (roughly 0.5-2.5 hours), though its active metabolite, 11-hydroxyyohimbine, persists for around 6 hours — which is closer to the effective duration researchers typically plan around. This short window is why it is commonly studied as a pre-activity compound, timed for peak effect around a research session or training window.

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Specifications

Tablets

100

Dose Per Tablet

10mg

Half-Life

~0.5-2.5 hours (active metabolite ~6 hours)

Administration

Oral

Chemical Structure

C21H26N2O3

Research Benefits

Stubborn Fat Mobilisation — Studied for blocking alpha-2 receptors concentrated in fat-resistant areas, promoting lipolysis.
Increased Energy and Focus — Frequently researched as a stimulant-based aid to alertness and workout intensity.
Appetite Research — Investigated for its influence on appetite signalling alongside its lipolytic effects.
Cardiovascular Response — Studied for its effect on heart rate and blood pressure via adrenergic pathways.
Fast Onset — A short half-life supports timed, pre-activity dosing protocols.

How It Works

Yohimbine functions as a selective antagonist at alpha-2 adrenergic receptors. These receptors are found in especially high density in stubborn, fat-resistant adipose tissue, where they normally act as a brake on lipolysis by inhibiting noradrenaline-driven fat breakdown.

By blocking this inhibitory signal, Yohimbine is studied for its ability to permit greater catecholamine-driven fat mobilisation in areas that typically resist other interventions. Its short half-life of around 5 hours means effects appear and clear quickly, a pharmacokinetic profile that has shaped its use as a timed, pre-activity research compound.

⚠ For Research Use Only

This product is supplied strictly for in-vitro laboratory and preclinical research use. It is not a drug, food, dietary supplement, or cosmetic, and is not intended for human or animal consumption, diagnosis, treatment, or prevention of any disease. Yohimbine must be handled only by qualified individuals trained in proper laboratory safety procedures.

By purchasing, the buyer confirms this product is being acquired for legitimate research purposes and assumes full responsibility for its handling, storage, and use in compliance with all applicable local, national, and international laws.